This study aimed to establish and compare normative metabolite concentrations in 2nd and 3rd trimester human amniotic fluid samples in an effort to reveal metabolic biomarkers of fetal health and development.
21 metabolite concentrations were compared between 2nd and 3rd trimester amniotic fluid samples using (1)H high resolution magic angle spinning (HR-MAS) spectroscopy. 16 of 21 metabolite concentrations differed significantly between 2nd and 3rd trimester groups. Betaine and creatinine concentrations increased significantly, while glucose, citrate, pyruvate, and numerous amino acid concentrations decreased significantly with advancing gestation.
These results provide key normative data for 2nd and 3rd trimester amniotic fluid metabolite concentrations and provide the foundation for future development of magnetic resonance spectroscopy (MRS) biomarkers to evaluate fetal health and development.
Cohn et al (2009). "Quantitative metabolic profiles of 2nd and 3rd trimester human amniotic fluid using (1)H HR-MAS spectroscopy." Magma. Epub Sept.
Tuesday, September 29, 2009
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