Colorectal cancer

This study prospectively examined the associations between dietary choline and betaine intake and risk of colorectal cancer in men in the Health Professionals Follow-up Study. They did not find any statistically significant associations between choline intake or betaine intake and risk of colorectal cancer. Comparing the top quintile with bottom quintile, multivariate relative risks (95% confidence interval) were 0.97 (0.79-1.20; Ptrend = 0.87) for choline intake and 0.94 (0.77-1.16; Ptrend = 0.79) for betaine intake.

Lee et al (2010). "Choline and Betaine Intake and the Risk of Colorectal Cancer in Men." Cancer Epidemiology Biomarkers & Prevention 19(3):1-4