Twelve men completed two 14-day experimental trials separated by a 14-day washout period, in a balanced, randomized, double-blind, repeated measures, crossover design. Prior to and following 14 days of twice daily betaine (B) or placebo (P) supplementation, subjects completed two consecutive days (D1 and D2) of a standardized high intensity strength/power resistance exercise challenge (REC). Performance included bench, squat, and jump tests.
Following 14-days of B supplementation, D1 and D2 bench throw power and isometric bench press force were increased during REC compared to pre-supplementation values and corresponding P values. Compared to pre-supplementation, vertical jump power and isometric squat force increased on D1 and D2 following B supplementation. However, there were no differences in jump squat power or the number of bench press or squat repetitions.
Therefore, B supplementation increased power, force and maintenance of these measures in selected performance measures, and these were more apparent in the smaller upper-body muscle groups.
Lee et al (2010). "Ergogenic effects of betaine supplementation on strength and power performance." Journal of the International Society of Sports Nutrition 7(1): 27.